InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHRS2

Summary

InnateDB Protein

IDBP-3409.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHRS2

Protein Name

dehydrogenase/reductase (SDR family) member 2

Synonyms

HEP27; SDR25C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000344674

InnateDB Gene

IDBG-3407 (DHRS2)

Protein Structure

UniProt Annotation

Function

Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21. {ECO:0000269PubMed:16685466, ECO:0000269PubMed:20547751}.

Subcellular Localization

Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes. {ECO:0000269PubMed:11944995}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004090	carbonyl reductase (NADPH) activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0008152	metabolic process
GO:0008207	C21-steroid hormone metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0009636	response to toxic substance
GO:0034599	cellular response to oxidative stress
GO:0043011	myeloid dendritic cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt