InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EGF

Summary

InnateDB Protein

IDBP-34102.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EGF

Protein Name

epidermal growth factor

Synonyms

HOMG4; URG;

Species

Homo sapiens

Ensembl Protein

ENSP00000265171

InnateDB Gene

IDBG-34100 (EGF)

Protein Structure

UniProt Annotation

Function

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. {ECO:0000269PubMed:17671655}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Hypomagnesemia 4 (HOMG4) [MIM:611718]: A disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to moderate psychomotor retardation, and brisk tendon reflexes. {ECO:0000269PubMed:17671655}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed in kidney, salivary gland, cerebrum and prostate. {ECO:0000269PubMed:17671655}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity

Biological Process

GO:0000186	activation of MAPKK activity
GO:0001525	angiogenesis
GO:0002576	platelet degranulation
GO:0006260	DNA replication
GO:0007165	signal transduction
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007262	STAT protein import into nucleus
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021940	positive regulation of cerebellar granule cell precursor proliferation
GO:0030168	platelet activation
GO:0035413	positive regulation of catenin import into nucleus
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0043388	positive regulation of DNA binding
GO:0043406	positive regulation of MAP kinase activity
GO:0045087	innate immune response
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0051048	negative regulation of secretion
GO:0060749	mammary gland alveolus development
GO:0070371	ERK1 and ERK2 cascade
GO:0090279	regulation of calcium ion import
GO:0090370	negative regulation of cholesterol efflux
GO:1900127	positive regulation of hyaluronan biosynthetic process
GO:2000008	regulation of protein localization to cell surface
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR016317 Pro-epidermal growth factor

PFAM

PF00058
PF00008
PF07645

PRINTS

PIRSF

PIRSF001778

SMART

SM00135
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt