InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHRS2

Summary

InnateDB Protein

IDBP-3411.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHRS2

Protein Name

dehydrogenase/reductase (SDR family) member 2

Synonyms

HEP27; SDR25C1;

Species

Homo sapiens

Ensembl Protein

ENSP00000250383

InnateDB Gene

IDBG-3407 (DHRS2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004090	carbonyl reductase (NADPH) activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0008152	metabolic process
GO:0008207	C21-steroid hormone metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0009636	response to toxic substance
GO:0034599	cellular response to oxidative stress
GO:0043011	myeloid dendritic cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt