Version 5.4
Homo sapiens Protein: ELL2
Summary
InnateDB Protein IDBP-34164.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ELL2
Protein Name elongation factor, RNA polymerase II, 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000237853
InnateDB Gene IDBG-34160 (ELL2)
Protein Structure
UniProt Annotation
Function Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane- specific to secretory IgH mRNA expression. {ECO:0000269PubMed:20159561, ECO:0000269PubMed:20471948, ECO:0000269PubMed:22195968, ECO:0000269PubMed:23251033}.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 18 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006368 transcription elongation from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0008023 transcription elongation factor complex
Protein Structure and Domains
PDB ID
InterPro IPR010844 Occludin/RNA polymerase II elongation factor, ELL domain
IPR019464 RNA polymerase II elongation factor ELL
PFAM PF07303
PF10390
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O00472
PhosphoSite PhosphoSite-O00472
TrEMBL Q59FW6
UniProt Splice Variant
Entrez Gene 22936
UniGene Hs.715914
RefSeq NP_036213
HUGO HGNC:17064
OMIM 601874
CCDS CCDS4080
HPRD 11798
IMGT
EMBL AB209343 AC008592 AK300310 BC028412 U88629
GenPept AAC51232 AAH28412 BAD92580 BAG62063

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca