InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POMC

Summary

InnateDB Protein

IDBP-34384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POMC

Protein Name

proopiomelanocortin

Synonyms

ACTH; CLIP; LPH; MSH; NPP; POC;

Species

Homo sapiens

Ensembl Protein

ENSP00000264708

InnateDB Gene

IDBG-34380 (POMC)

Protein Structure

UniProt Annotation

Function

ACTH stimulates the adrenal glands to release cortisol.MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.Beta-endorphin and Met-enkephalin are endogenous opiates.

Subcellular Localization

Secreted.

Disease Associations

Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269PubMed:12165561}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.Pro-opiomelanocortinin deficiency (POMCD) [MIM:609734]: Affected individuals present early-onset obesity, adrenal insufficiency and red hair. {ECO:0000269PubMed:9620771}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

ACTH and MSH are produced by the pituitary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0005102	receptor binding
GO:0005179	hormone activity
GO:0031781	type 3 melanocortin receptor binding
GO:0031782	type 4 melanocortin receptor binding
GO:0070996	type 1 melanocortin receptor binding

Biological Process

GO:0006091	generation of precursor metabolites and energy
GO:0007165	signal transduction
GO:0007218	neuropeptide signaling pathway
GO:0007267	cell-cell signaling
GO:0008217	regulation of blood pressure
GO:0016486	peptide hormone processing
GO:0032098	regulation of appetite
GO:0032720	negative regulation of tumor necrosis factor production
GO:0033059	cellular pigmentation
GO:0044267	cellular protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005782	peroxisomal matrix
GO:0030141	secretory granule
GO:0034774	secretory granule lumen

Protein Structure and Domains

PDB ID

InterPro

IPR001941 Pro-opiomelanocortin/corticotropin, ACTH
IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central region
IPR013532 Opiodes neuropeptide
IPR013593 Pro-opiomelanocortin N-terminal

PFAM

PF00976
PF08035
PF08384

PRINTS

PR00383

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P01189