InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZHX2

Summary

InnateDB Protein

IDBP-34398.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZHX2

Protein Name

zinc fingers and homeoboxes 2

Synonyms

AFR1; RAF;

Species

Homo sapiens

Ensembl Protein

ENSP00000314709

InnateDB Gene

IDBG-34396 (ZHX2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA. {ECO:0000269PubMed:12741956}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108, ECO:0000269PubMed:12741956, ECO:0000269PubMed:17056598}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Expressed in podocytes. {ECO:0000269PubMed:12741956, ECO:0000269PubMed:17056598}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006402	mRNA catabolic process
GO:0035019	somatic stem cell maintenance
GO:0045665	negative regulation of neuron differentiation
GO:0045892	negative regulation of transcription, DNA-templated