InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNMT3A

Summary

InnateDB Protein

IDBP-34451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNMT3A

Protein Name

DNA (cytosine-5-)-methyltransferase 3 alpha

Synonyms

DNMT3A2; M.HsaIIIA; TBRS;

Species

Homo sapiens

Ensembl Protein

ENSP00000370122

InnateDB Gene

IDBG-34441 (DNMT3A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 90 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	90 [view]
Protein-Protein	86 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003886	DNA (cytosine-5-)-methyltransferase activity
GO:0005515	protein binding
GO:0008168	methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006306	DNA methylation
GO:0006349	regulation of gene expression by genetic imprinting
GO:0090116	C-5 methylation of cytosine

Cellular Component

GO:0000791	euchromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000313 PWWP domain
IPR001525 C-5 cytosine methyltransferase
IPR011011 Zinc finger, FYVE/PHD-type
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00855
PF00145

PRINTS

PR00105

PIRSF

SMART

SM00293

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt