Version 5.4
Homo sapiens Protein: TRMT12
Summary
InnateDB Protein IDBP-34960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRMT12
Protein Name tRNA methyltransferase 12 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000329858
InnateDB Gene IDBG-34958 (TRMT12)
Protein Structure
UniProt Annotation
Function S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha- carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. {ECO:0000269PubMed:22761755}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016740 transferase activity
Biological Process
GO:0008033 tRNA processing
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003402 tRNA transferase Trm5/Tyw2
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF02475
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q53H54
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 55039
UniGene Hs.9925
RefSeq NP_060426
HUGO HGNC:26091
OMIM 611244
CCDS CCDS6349
HPRD 07947
IMGT
EMBL AK000779 AK222727 BC003057 BC011713
GenPept AAH03057 AAH11713 BAA91374 BAD96447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca