InnateDB Protein
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IDBP-35243.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TPM4
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Protein Name
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tropomyosin 4
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Synonyms
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HEL-S-108;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000345230
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InnateDB Gene
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IDBG-35241 (TPM4)
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Protein Structure
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Function |
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium. {ECO:0000269PubMed:1836432}.
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Subcellular Localization |
Cytoplasm, cytoskeleton.
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Disease Associations |
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Tissue Specificity |
Detected in cardiac tissue and platelets, the form found in cardiac tissue is a higher molecular weight than the form found in platelets. Expressed at higher levels in the platelets of hypertensive patients with cardiac hypertrophy than in the platelets of hypertensive patients without cardiac hypertrophy (at protein level). {ECO:0000269PubMed:1836432}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
47
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000533
Tropomyosin
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PFAM |
PF00261
PF12718
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PRINTS |
PR00194
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P67936
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PhosphoSite |
PhosphoSite-P67936
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TrEMBL |
K7EPV9
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UniProt Splice Variant |
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Entrez Gene |
7171
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UniGene |
Hs.707554
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RefSeq |
NP_001138632
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HUGO |
HGNC:12013
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OMIM |
600317
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CCDS |
CCDS46007
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HPRD |
11734
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IMGT |
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EMBL |
AC008894
AK023385
AK315076
BC002827
BC037576
BC067225
BT019634
CH471106
M12127
X05276
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GenPept |
AAA36774
AAH02827
AAH37576
AAH67225
AAV38440
BAB14554
BAG37545
CAA28888
EAW84521
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