InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MBD2

Summary

InnateDB Protein

IDBP-3534.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MBD2

Protein Name

methyl-CpG binding domain protein 2

Synonyms

DMTase; NY-CO-41;

Species

Homo sapiens

Ensembl Protein

ENSP00000256429

InnateDB Gene

IDBG-3532 (MBD2)

Protein Structure

UniProt Annotation

Function

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269PubMed:10471499, ECO:0000269PubMed:10947852, ECO:0000269PubMed:12665568, ECO:0000269PubMed:16415179, ECO:0000269PubMed:24307175, ECO:0000269PubMed:9774669}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12183469, ECO:0000269PubMed:9774669}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase.

Disease Associations

Tissue Specificity

Highly expressed in brain, heart, kidney, stomach, testis and placenta. {ECO:0000269PubMed:10050851}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	56 [view]
Protein-Protein	47 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003696	satellite DNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0019904	protein domain specific binding
GO:0031492	nucleosomal DNA binding
GO:0035197	siRNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030177	positive regulation of Wnt signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042711	maternal behavior
GO:0043044	ATP-dependent chromatin remodeling
GO:0043623	cellular protein complex assembly
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043234	protein complex