InnateDB Protein
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IDBP-35512.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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EIF4B
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Protein Name
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eukaryotic translation initiation factor 4B
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Synonyms
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EIF-4B; PRO1843;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000262056
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InnateDB Gene
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IDBG-35510 (EIF4B)
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Protein Structure
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Function |
Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'- terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
70
[view]
|
Protein-Protein |
69
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
P23588
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PhosphoSite |
PhosphoSite-P23588
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
1975
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UniGene |
Hs.729387
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RefSeq |
NP_001408
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HUGO |
HGNC:3285
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OMIM |
603928
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CCDS |
CCDS41788
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HPRD |
04892
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IMGT |
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EMBL |
AB076839
AK222528
BC073139
BC073154
BC098437
CH471054
CR456958
X55733
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GenPept |
AAH73139
AAH73154
AAH98437
BAB82380
BAD96248
CAA39265
CAG33239
EAW96657
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