InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SUGT1

Summary

InnateDB Protein

IDBP-35707.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUGT1

Protein Name

SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)

Synonyms

SGT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000367208

InnateDB Gene

IDBG-35701 (SUGT1)

Protein Structure

UniProt Annotation

Function

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:21864708}. Nucleus {ECO:0000269PubMed:21864708}. Note=Translocates to the nucleus upon heat shock, requiring S100A6.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.

Experimentally validated
Total	102 [view]
Protein-Protein	97 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007067	mitotic nuclear division
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR007052 CS domain
IPR007699 SGS
IPR008978 HSP20-like chaperone
IPR013026 Tetratricopeptide repeat-containing domain
IPR019734 Tetratricopeptide repeat

PFAM

PF04969
PF05002
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y2Z0