Version 5.4
Homo sapiens Protein: FABP2
Summary
InnateDB Protein IDBP-35743.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FABP2
Protein Name fatty acid binding protein 2, intestinal
Synonyms FABPI; I-FABP;
Species Homo sapiens
Ensembl Protein ENSP00000274024
InnateDB Gene IDBG-35741 (FABP2)
Protein Structure
UniProt Annotation
Function FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Expressed in the small intestine and at much lower levels in the large intestine. Highest expression levels in the jejunum. {ECO:0000269PubMed:14563446}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005504 fatty acid binding
Biological Process
GO:0006810 transport
GO:0007586 digestion
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR011038 Calycin-like
PFAM PF00061
PF08212
PRINTS PR00178
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P12104
PhosphoSite PhosphoSite-P12104
TrEMBL
UniProt Splice Variant
Entrez Gene 2169
UniGene Hs.282265
RefSeq NP_000125
HUGO HGNC:3556
OMIM 134640
CCDS CCDS3712
HPRD 00611
IMGT
EMBL AC092656 BC069466 BC069617 BC069625 BC069637 BC111791 M18079
GenPept AAA52417 AAH69466 AAH69617 AAH69625 AAH69637 AAI11792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca