InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC26A3

Summary

InnateDB Protein

IDBP-35755.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A3

Protein Name

solute carrier family 26, member 3

Synonyms

CLD; DRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000345873

InnateDB Gene

IDBG-35753 (SLC26A3)

Protein Structure

UniProt Annotation

Function

Chloride/bicarbonate exchanger. Mediates the efficient absorption of chloride ions in the colon, participating in fluid homeostasis. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.

Subcellular Localization

Apical cell membrane {ECO:0000269PubMed:22159084}; Multi-pass membrane protein {ECO:0000269PubMed:22159084}. Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250}.

Disease Associations

Diarrhea 1, secretory chloride, congenital (DIAR1) [MIM:214700]: A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. {ECO:0000269PubMed:11524734, ECO:0000269PubMed:19861545, ECO:0000269PubMed:21150650, ECO:0000269PubMed:21394828, ECO:0000269PubMed:8896562, ECO:0000269PubMed:9554749, ECO:0000269PubMed:9718329}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0007588	excretion
GO:0008272	sulfate transport
GO:0015701	bicarbonate transport
GO:0048240	sperm capacitation
GO:0051454	intracellular pH elevation
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071320	cellular response to cAMP
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0097225	sperm midpiece