InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LECT1

Summary

InnateDB Protein

IDBP-35926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LECT1

Protein Name

leukocyte cell derived chemotaxin 1

Synonyms

BRICD3; CHM-I; CHM1; MYETS1;

Species

Homo sapiens

Ensembl Protein

ENSP00000367198

InnateDB Gene

IDBG-35924 (LECT1)

Protein Structure

UniProt Annotation

Function

Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000269PubMed:16980969}.

Subcellular Localization

Chondromodulin-1: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter- territorial matrix of cartilage.Chondrosurfactant protein: Endomembrane system {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma. {ECO:0000269PubMed:16980969}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001501	skeletal system development
GO:0001886	endothelial cell morphogenesis
GO:0001937	negative regulation of endothelial cell proliferation
GO:0006029	proteoglycan metabolic process
GO:0016525	negative regulation of angiogenesis
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0051216	cartilage development