InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SEMA3F

Summary

InnateDB Protein

IDBP-35946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEMA3F

Protein Name

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F

Synonyms

SEMA-IV; SEMA4; SEMAK;

Species

Homo sapiens

Ensembl Protein

ENSP00000002829

InnateDB Gene

IDBG-35942 (SEMA3F)

Protein Structure

UniProt Annotation

Function

May play a role in cell motility and cell adhesion.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed abundantly but differentially in a variety of neural and nonneural tissues. There is high expression in mammary gland, kidney, fetal brain, and lung and lower expression in heart and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0045499	chemorepellent activity

Biological Process

GO:0001755	neural crest cell migration
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0021612	facial nerve structural organization
GO:0021637	trigeminal nerve structural organization
GO:0021675	nerve development
GO:0021785	branchiomotor neuron axon guidance
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0061549	sympathetic ganglion development
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance

Cellular Component

GO:0005615	extracellular space
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001627 Sema domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR016201 Plexin-like fold

PFAM

PF01403

PRINTS

PIRSF

SMART

SM00630
SM00408
SM00409
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q13275