InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUDT12

Summary

InnateDB Protein

IDBP-36033.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUDT12

Protein Name

nudix (nucleoside diphosphate linked moiety X)-type motif 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000230792

InnateDB Gene

IDBG-36029 (NUDT12)

Protein Structure

UniProt Annotation

Function

Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. {ECO:0000269PubMed:12790796}.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:12790796}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000210	NAD+ diphosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0035529	NADH pyrophosphatase activity
GO:0046872	metal ion binding

Biological Process

GO:0006742	NADP catabolic process
GO:0019677	NAD catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005777	peroxisome

Protein Structure and Domains

PDB ID

InterPro

IPR000086 NUDIX hydrolase domain
IPR002110 Ankyrin repeat
IPR015375 NADH pyrophosphatase-like, N-terminal
IPR015376 Zinc ribbon, NADH pyrophosphatase
IPR015797 NUDIX hydrolase domain-like
IPR020683 Ankyrin repeat-containing domain

PFAM