InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIGIRR

Summary

InnateDB Protein

IDBP-360624.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIGIRR

Protein Name

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000403104

InnateDB Gene

IDBG-16551 (SIGIRR)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269PubMed:12925853, ECO:0000269PubMed:14715412, ECO:0000269PubMed:15866876}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Mainly expressed in epithelial tissues such as kidney, lung and gut. {ECO:0000269PubMed:14715412, ECO:0000269PubMed:21077278}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001960	negative regulation of cytokine-mediated signaling pathway
GO:0006953	acute-phase response
GO:0007165	signal transduction
GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045079	negative regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)