Homo sapiens Protein: CPSF3L
Summary
InnateDB Protein IDBP-361384.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPSF3L
Protein Name cleavage and polyadenylation specific factor 3-like
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000404886
InnateDB Gene IDBG-85005 (CPSF3L)
Protein Structure
UniProt Annotation
Function Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. {ECO:0000269PubMed:16239144}.
Subcellular Localization Nucleus {ECO:0000269PubMed:15684398}. Cytoplasm {ECO:0000269PubMed:15684398}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016787 hydrolase activity
Biological Process
GO:0008152 metabolic process
GO:0016180 snRNA processing
Cellular Component
GO:0005737 cytoplasm
GO:0032039 integrator complex
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR001279 Beta-lactamase-like
IPR011108 RNA-metabolising metallo-beta-lactamase
IPR022712 Beta-Casp domain
PFAM PF00753
PF07521
PF10996
PRINTS
PIRSF
SMART SM00849
SM01027
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5TA45
PhosphoSite PhosphoSite-Q5TA45
TrEMBL J3QRY6
UniProt Splice Variant
Entrez Gene 54973
UniGene Hs.739302
RefSeq NP_001243392
HUGO HGNC:26052
OMIM 611354
CCDS CCDS57961
HPRD 13377
IMGT
EMBL AK000549 AK021939 AK023356 AK056652 AK291387 AK297350 AL136813 AL139287 BC000675 BC007978 BC013904 BK005673 BK005728 CH471183 CR533557
GenPept AAH00675 AAH07978 AAH13904 BAA91246 BAB13943 BAB14541 BAF84076 BAG51775 BAG59799 CAB66747 CAG38588 CAI23174 CAI23176 CAI23177 CAI23179 CAI23180 CAI23181 DAA05669 DAA05728 EAW56235 EAW56238 EAW56239 EAW56240 EAW56242