Version 5.4
Homo sapiens Protein: ARPC4
Summary
InnateDB Protein IDBP-361935.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARPC4
Protein Name actin related protein 2/3 complex, subunit 4, 20kDa
Synonyms ARC20; P20-ARC;
Species Homo sapiens
Ensembl Protein ENSP00000388169
InnateDB Gene IDBG-407641 (ARPC4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 53 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0030674 protein binding, bridging
GO:0051015 actin filament binding
Biological Process
GO:0030041 actin filament polymerization
GO:0034314 Arp2/3 complex-mediated actin nucleation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045010 actin nucleation
GO:0045087 innate immune response
Cellular Component
GO:0005829 cytosol
GO:0005885 Arp2/3 protein complex
GO:0015629 actin cytoskeleton
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR008384 ARP2/3 complex, 20kDa subunit (P20-Arc)
PFAM PF05856
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P59998
PhosphoSite PhosphoSite-P59998
TrEMBL R4GN08
UniProt Splice Variant
Entrez Gene 10093
UniGene
RefSeq NP_001185709
HUGO HGNC:707
OMIM 604226
CCDS CCDS56238
HPRD 10368
IMGT
EMBL AC022382 AF006087 AF019888 BC012596 BC025289 BX419672
GenPept AAB64192 AAB71548 AAH12596

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca