Homo sapiens Protein: MTRR | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-362093.5 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | MTRR | ||||||||||||||||||||||||||
Protein Name | 5-methyltetrahydrofolate-homocysteine methyltransferase reductase | ||||||||||||||||||||||||||
Synonyms | cblE; MSR; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000402510 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-12013 (MTRR) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the maintenance of methionine synthase in a functional state. Necessary for utilization of methylgroups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Folate pathway donates methyl groups necessary for cellular methylation and affects different pathways such as DNA methylation, possibly explaining the transgenerational epigenetic inheritance effects. {ECO:0000269PubMed:17892308}. | ||||||||||||||||||||||||||
Subcellular Localization | Isoform B: Cytoplasm.Isoform C: Cytoplasm.Isoform A: Cytoplasm {ECO:0000269PubMed:18221906}. | ||||||||||||||||||||||||||
Disease Associations | Homocystinuria-megaloblastic anemia, cblE complementation type (HMAE) [MIM:236270]: An autosomal recessive inborn error of metabolism resulting from defects in the cobalamin-dependent pathway that converts homocysteine to methionine. It causes delayed psychomotor development, megaloblastic anemia, homocystinuria, and hypomethioninemia. Cells from patients with HMAE fail to incorporate methyltetrahydrofolate into methionine in whole cells, but cell extracts show normal methionine synthase activity in the presence of a reducing agent. {ECO:0000269PubMed:10484769, ECO:0000269PubMed:9501215}. Note=The disease is caused by mutations affecting the gene represented in this entry.Folate-sensitive neural tube defects (FS-NTD) [MIM:601634]: The most common NTDs are open spina bifida (myelomeningocele) and anencephaly. {ECO:0000269PubMed:10444342, ECO:0000269PubMed:12375236}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||||||||||||||||||||||||||
Tissue Specificity | Found in all tissues tested, particularly abundant in skeletal muscle. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR001094
Flavodoxin IPR001433 Oxidoreductase FAD/NAD(P)-binding IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase IPR003097 FAD-binding, type 1 IPR008254 Flavodoxin/nitric oxide synthase IPR017938 Riboflavin synthase-like beta-barrel IPR029039 Flavoprotein-like |
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PFAM |
PF00175
PF00667 PF00258 |
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PRINTS |
PR00369
PR00371 |
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PIRSF | |||||||||||||||||||||||||||
SMART | |||||||||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | Q9UBK8 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9UBK8 | ||||||||||||||||||||||||||
TrEMBL | D6RIS8 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 4552 | ||||||||||||||||||||||||||
UniGene | Hs.481551 | ||||||||||||||||||||||||||
RefSeq | NP_002445 | ||||||||||||||||||||||||||
HUGO | HGNC:7473 | ||||||||||||||||||||||||||
OMIM | 602568 | ||||||||||||||||||||||||||
CCDS | CCDS47190 | ||||||||||||||||||||||||||
HPRD | 03979 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AC010346 AC025174 AF025794 AF121202 AF121203 AF121204 AF121205 AF121206 AF121207 AF121208 AF121209 AF121210 AF121211 AF121212 AF121213 AF121214 BC054816 BC109216 | ||||||||||||||||||||||||||
GenPept | AAC39667 AAF16876 AAF17303 AAF17304 AAH54816 AAI09217 | ||||||||||||||||||||||||||