InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NTF3

Summary

InnateDB Protein

IDBP-362497.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTF3

Protein Name

neurotrophin 3

Synonyms

HDNF; NGF-2; NGF2; NT-3; NT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000397297

InnateDB Gene

IDBG-13412 (NTF3)

Protein Structure

UniProt Annotation

Function

Seems to promote the survival of visceral and proprioceptive sensory neurons.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Brain and peripheral tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005165	neurotrophin receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042056	chemoattractant activity
GO:0048406	nerve growth factor binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0002092	positive regulation of receptor internalization
GO:0007165	signal transduction
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007267	cell-cell signaling
GO:0007274	neuromuscular synaptic transmission
GO:0007399	nervous system development
GO:0007403	glial cell fate determination
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007422	peripheral nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0008544	epidermis development
GO:0021675	nerve development
GO:0030335	positive regulation of cell migration
GO:0032148	activation of protein kinase B activity
GO:0032856	activation of Ras GTPase activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042490	mechanoreceptor differentiation
GO:0042552	myelination
GO:0043523	regulation of neuron apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0045687	positive regulation of glial cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048484	enteric nervous system development
GO:0048666	neuron development
GO:0048699	generation of neurons
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation
GO:0050804	regulation of synaptic transmission
GO:0050918	positive chemotaxis
GO:0050930	induction of positive chemotaxis
GO:0051145	smooth muscle cell differentiation
GO:2000251	positive regulation of actin cytoskeleton reorganization