InnateDB Protein
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IDBP-362748.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ACE2
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Protein Name
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angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000389326
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InnateDB Gene
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IDBG-46534 (ACE2)
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Protein Structure
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Function |
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. {ECO:0000269PubMed:10924499, ECO:0000269PubMed:10969042, ECO:0000269PubMed:14647384, ECO:0000269PubMed:24227843}.
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Subcellular Localization |
Processed angiotensin-converting enzyme 2: Secreted.Cell membrane; Single-pass type I membrane protein. Cytoplasm {ECO:0000250}. Note=Detected in both cell membrane and cytoplasm in neurons. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level). Expressed in heart, kidney, testis, and gastrointestinal system. {ECO:0000269PubMed:10924499, ECO:0000269PubMed:10969042, ECO:0000269PubMed:12459472, ECO:0000269PubMed:15141377, ECO:0000269PubMed:15231706, ECO:0000269PubMed:15671045}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001548
Peptidase M2, peptidyl-dipeptidase A
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PFAM |
PF01401
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PRINTS |
PR00791
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BYF1
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PhosphoSite |
PhosphoSite-Q9BYF1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
59272
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UniGene |
Hs.599579
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RefSeq |
NP_068576
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HUGO |
HGNC:13557
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OMIM |
300335
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CCDS |
CCDS14169
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HPRD |
02274
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IMGT |
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EMBL |
AB046569
AB193259
AB193260
AF241254
AF291820
AL110224
AY217547
AY358714
AY623811
BC039902
BC048094
CH471074
E39033
GQ262784
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GenPept |
AAF78220
AAF99721
AAH39902
AAH48094
AAO25651
AAQ89076
AAT45083
ACT66268
BAB40370
BAD99266
BAD99267
CAB53682
EAW98892
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