Version 5.4
Homo sapiens Protein: FBXL5
Summary
InnateDB Protein IDBP-363443.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL5
Protein Name F-box and leucine-rich repeat protein 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000408679
InnateDB Gene IDBG-10508 (FBXL5)
Protein Structure
UniProt Annotation
Function Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. {ECO:0000269PubMed:17532294, ECO:0000269PubMed:19762596, ECO:0000269PubMed:19762597}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:17532294}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
Biological Process
GO:0016567 protein ubiquitination
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0055072 iron ion homeostasis
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0019005 SCF ubiquitin ligase complex
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001611 Leucine-rich repeat
IPR001810 F-box domain
IPR006553 Leucine-rich repeat, cysteine-containing subtype
PFAM PF00560
PF13504
PF13855
PF00646
PF12937
PF13013
PRINTS
PIRSF
SMART SM00256
SM00367
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKA1
PhosphoSite PhosphoSite-Q9UKA1
TrEMBL D6RHC3
UniProt Splice Variant
Entrez Gene 26234
UniGene
RefSeq NP_001180464
HUGO HGNC:13602
OMIM 605655
CCDS CCDS54745
HPRD 05739
IMGT
EMBL AC114744 AC116651 AF142481 AF157323 AF174591 AF176700 AF199420 AK000153 AK295510 BC030656 BX537957 CH471069
GenPept AAF03700 AAF04512 AAF09249 AAF66616 AAF67489 AAH30656 AAY40929 BAA90978 BAG58427 CAD97924 EAW92737 EAW92739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca