InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCNA2

Summary

InnateDB Protein

IDBP-36374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCNA2

Protein Name

cyclin A2

Synonyms

CCN1; CCNA;

Species

Homo sapiens

Ensembl Protein

ENSP00000274026

InnateDB Gene

IDBG-36372 (CCNA2)

Protein Structure

UniProt Annotation

Function

Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17698606}. Cytoplasm {ECO:0000269PubMed:17698606}. Note=Cytoplasmic when associated with SCAPER.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 120 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	120 [view]
Protein-Protein	111 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0007095	mitotic G2 DNA damage checkpoint
GO:0007265	Ras protein signal transduction
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0031100	organ regeneration
GO:0032355	response to estradiol
GO:0033762	response to glucagon
GO:0045087	innate immune response (InnateDB)
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048146	positive regulation of fibroblast proliferation
GO:0051726	regulation of cell cycle