InnateDB Protein
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IDBP-364035.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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GMPR2
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Protein Name
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guanosine monophosphate reductase 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000392859
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InnateDB Gene
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IDBG-3727 (GMPR2)
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Protein Structure
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Function |
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation. {ECO:0000269PubMed:12009299, ECO:0000269PubMed:12669231, ECO:0000269PubMed:16359702, ECO:0000269PubMed:22037469}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes. {ECO:0000269PubMed:12009299, ECO:0000269PubMed:12669231}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000262
FMN-dependent dehydrogenase
IPR001093
IMP dehydrogenase/GMP reductase
IPR005993
Guanosine monophosphate reductase 1
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PFAM |
PF01070
PF00478
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PRINTS |
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PIRSF |
PIRSF000235
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9P2T1
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PhosphoSite |
PhosphoSite-Q9P2T1
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TrEMBL |
Q86SZ5
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UniProt Splice Variant |
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Entrez Gene |
51292
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UniGene |
Hs.368855
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RefSeq |
NP_057660
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HUGO |
HGNC:4377
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OMIM |
610781
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CCDS |
CCDS45087
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HPRD |
13590
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IMGT |
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EMBL |
AB032903
AF135159
AF419346
AL096870
BC008021
BC009832
BC093039
BX161436
BX161518
BX247993
CH471078
CR457156
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GenPept |
AAG09132
AAH08021
AAH09832
AAH93039
AAN32701
BAA93080
CAD61908
CAD61951
CAD62327
CAG33437
EAW66051
EAW66053
EAW66054
EAW66056
EAW66057
EAW66058
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