Version 5.4
Homo sapiens Protein: ANO8
Summary
InnateDB Protein IDBP-36404.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANO8
Protein Name anoctamin 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000159087
InnateDB Gene IDBG-36402 (ANO8)
Protein Structure
UniProt Annotation
Function Does not exhibit calcium-activated chloride channel (CaCC) activity.
Subcellular Localization Cell membrane {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22946059}; Multi-pass membrane protein {ECO:0000269PubMed:20056604, ECO:0000269PubMed:22946059}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
Disease Associations
Tissue Specificity Expressed in embryonic stem cells, fetal brain and neural tissues. {ECO:0000269PubMed:15647853}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005229 intracellular calcium activated chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR007632 Anoctamin
PFAM PF04547
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9HCE9
PhosphoSite PhosphoSite-Q9HCE9
TrEMBL
UniProt Splice Variant
Entrez Gene 57719
UniGene Hs.590990
RefSeq NP_066010
HUGO HGNC:29329
OMIM 610216
CCDS CCDS32949
HPRD 17223
IMGT
EMBL AB046843 AC010463 CH471106
GenPept BAB13449 EAW84595

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca