InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FZR1

Summary

InnateDB Protein

IDBP-364190.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FZR1

Protein Name

fizzy/cell division cycle 20 related 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410369

InnateDB Gene

IDBG-17274 (FZR1)

Protein Structure

UniProt Annotation

Function

Key regulator of ligase activity of the anaphase promoting complex/cyclosome (APC/C), which confers substrate specificity upon the complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. {ECO:0000269PubMed:18662541, ECO:0000269PubMed:21596315, ECO:0000269PubMed:9734353}.

Subcellular Localization

Isoform 2: Nucleus.Isoform 3: Cytoplasm.

Disease Associations

Tissue Specificity

Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. {ECO:0000269PubMed:12797865}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	123 [view]
Protein-Protein	123 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006281	DNA repair
GO:0007067	mitotic nuclear division
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031572	G2 DNA damage checkpoint
GO:0045732	positive regulation of protein catabolic process
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051488	activation of anaphase-promoting complex activity
GO:0070979	protein K11-linked ubiquitination