InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TBXA2R

Summary

InnateDB Protein

IDBP-364350.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TBXA2R

Protein Name

thromboxane A2 receptor

Synonyms

BDPLT13; TXA2-R;

Species

Homo sapiens

Ensembl Protein

ENSP00000393333

InnateDB Gene

IDBG-17506 (TBXA2R)

Protein Structure

UniProt Annotation

Function

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. {ECO:0000269PubMed:8613548}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Bleeding disorder, platelet-type 13 (BDPLT13) [MIM:614009]: A disorder characterized by reduced platelet aggregation and a tendency to mild mucocutaneous bleeding. {ECO:0000269PubMed:7929844}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.

Experimentally validated
Total	60 [view]
Protein-Protein	57 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004960	thromboxane receptor activity
GO:0004961	thromboxane A2 receptor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0006954	inflammatory response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0019229	regulation of vasoconstriction
GO:0019932	second-messenger-mediated signaling
GO:0030168	platelet activation
GO:0032496	response to lipopolysaccharide
GO:0038193	thromboxane A2 signaling pathway
GO:0042493	response to drug
GO:0043547	positive regulation of GTPase activity
GO:0045766	positive regulation of angiogenesis
GO:0045777	positive regulation of blood pressure
GO:0045907	positive regulation of vasoconstriction
GO:0045987	positive regulation of smooth muscle contraction