InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DNAJB9

Summary

InnateDB Protein

IDBP-36487.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNAJB9

Protein Name

DnaJ (Hsp40) homolog, subfamily B, member 9

Synonyms

ERdj4; MDG-1; MDG1; MST049; MSTP049;

Species

Homo sapiens

Ensembl Protein

ENSP00000249356

InnateDB Gene

IDBG-36485 (DNAJB9)

Protein Structure

UniProt Annotation

Function

Involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Acts as a co-chaperone with an Hsp70 protein. {ECO:0000269PubMed:18400946}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	14 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051787	misfolded protein binding

Biological Process

GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0070062	extracellular vesicular exosome