InnateDB Protein
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IDBP-365371.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RIC3
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Protein Name
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resistance to inhibitors of cholinesterase 3 homolog (C. elegans)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000404415
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InnateDB Gene
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IDBG-30545 (RIC3)
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Protein Structure
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Function |
Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4. {ECO:0000269PubMed:12821669, ECO:0000269PubMed:15504725, ECO:0000269PubMed:15809299, ECO:0000269PubMed:15927954, ECO:0000269PubMed:16120769, ECO:0000269PubMed:17609200, ECO:0000269PubMed:18691158}.
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Subcellular Localization |
Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein.Isoform 2: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single- pass membrane protein.
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Disease Associations |
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Tissue Specificity |
Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain. {ECO:0000269PubMed:12821669, ECO:0000269PubMed:17640815, ECO:0000269PubMed:18691158}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7Z5B4
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PhosphoSite |
PhosphoSite-Q7Z5B4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
79608
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UniGene |
Hs.231850
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RefSeq |
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HUGO |
HGNC:30338
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OMIM |
610509
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CCDS |
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HPRD |
17974
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IMGT |
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EMBL |
AC091013
AC116456
AC129895
AK021670
AK315379
AL832601
AM422214
AY326435
AY326436
AY358475
BC022455
CH471064
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GenPept |
AAH22455
AAP92162
AAP92163
AAQ88839
BAB13871
BAG37772
CAD89943
CAM12309
EAW68628
EAW68630
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