Version 5.4
Homo sapiens Protein: LAMP5
Summary
InnateDB Protein IDBP-366214.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMP5
Protein Name chromosome 20 open reading frame 103
Synonyms BAD-LAMP; BADLAMP; C20orf103; LAMP-5; UNC-43;
Species Homo sapiens
Ensembl Protein ENSP00000406360
InnateDB Gene IDBG-53539 (LAMP5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Cell membrane {ECO:0000269PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269PubMed:21642595}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269PubMed:21642595}. Endosome membrane {ECO:0000269PubMed:21642595}; Single-pass type I membrane protein {ECO:0000269PubMed:21642595}. Cytoplasmic vesicle {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, growth cone membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Recycling endosome {ECO:0000250}. Note=Localized mostly in cytoplasmic vesicles of neuronal cell body. Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles. Accumulates in the endoplasmic reticulum- Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides. Associates with cortical membranes. {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in plasmocytoid dendritic cells. Expressed in suprabasal skin keratinocytes and squamous cells (at protein level). Expressed in the brain and weakly in spleen and skin. Expressed in plasmocytoid dendritic cells. {ECO:0000269PubMed:21642595}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0030659 cytoplasmic vesicle membrane
GO:0031901 early endosome membrane
GO:0032584 growth cone membrane
GO:0032590 dendrite membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0055038 recycling endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR002000 Lysosome-associated membrane glycoprotein
PFAM PF01299
PRINTS PR00336
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UJQ1
PhosphoSite PhosphoSite-Q9UJQ1
TrEMBL
UniProt Splice Variant
Entrez Gene 24141
UniGene Hs.22920
RefSeq NP_001186826
HUGO HGNC:16097
OMIM 614641
CCDS CCDS56177
HPRD 12736
IMGT
EMBL AK295336 AK316114 AL031652 AL121740 BC050727
GenPept AAH50727 BAG58309 BAH14485 CAB57330 CAC18101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca