InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TP53

Summary

InnateDB Protein

IDBP-366324.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TP53

Protein Name

tumor protein p53

Synonyms

BCC7; LFS1; P53; TRP53;

Species

Homo sapiens

Ensembl Protein

ENSP00000410739

InnateDB Gene

IDBG-26364 (TP53)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1328 experimentally validated interaction(s) in this database.
They are also associated with 85 interaction(s) predicted by orthology.

Experimentally validated
Total	1328 [view]
Protein-Protein	1244 [view]
Protein-DNA	66 [view]
Protein-RNA	0
DNA-DNA	18 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	85 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002117 p53 tumour suppressor family
IPR008967 p53-like transcription factor, DNA-binding
IPR011615 p53, DNA-binding domain
IPR013872 p53 transactivation domain

PFAM

PF00870
PF08563

PRINTS

PR00386

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB118156 AC007421 AC087388 AY627884 DQ486039 DQ812984 EF178467 EF178468 EF178469 EF445599 EF445600 EF445601 EF445602 EF445603 EF445604 EF445605 EF445606 EF445607 EF445608 EF445609 EF445610 EF445611 EF445612 EF445613 EF445614 EF445615 EF445616 EF445617 EF445618 EF445619 EF445620 EF445621 EF445622 EF445623 EF445624 EF445625 EF445626 EF680844 EU523098 EU856041 JF923567 JF923570 JF923571 JF923572 JQ751621 JQ751622 JQ751623 JQ751624 JQ751626 JQ751627 JQ751628 JQ751629 JQ751630 JQ751631 JQ751632 JQ751633 JQ751634 JQ751635 JQ751636 JQ751637 JQ751638 JQ751639 JQ751640 JQ751641 JQ751642 JQ751643 JQ751644 JQ751645 JQ751646 JQ751647 JQ751648 JQ751650 JQ751651 JQ751652 JQ751654 JQ751655 JQ751656 JQ751657 JQ751658 JQ751659 JQ751660 JQ751661 JQ751662 JQ751663 JQ751664 JQ751665 JQ751666 JQ751667 JQ751668 JQ751669 JQ751670 JQ751671 JQ751672 JQ751673 JQ751674 JQ751675 JQ751676 JQ751677 JQ751678 JQ751679 JQ751680 JQ751681 JQ751682 JQ751683 JQ751684 JQ751685 JQ751686 JQ751687 JQ751688 JQ751689 JQ751690 JQ751691 JQ751692 JQ751693 JQ751694 JQ751695 JQ751696 JQ751697 JQ751698 JQ751699 JQ751700 JQ751701 JQ751702 JQ751703 JQ751704 JQ751705 JQ751706 JQ751707 JQ751708 JQ751709 JQ751710 JQ751711 JQ751712 JQ751713 JQ751714 JQ751715 JQ751716 JQ751717 JQ751718 JQ751719 JQ751720 JQ751721 JQ751722 JQ751723 JQ751724 JQ751725 JQ751726 JQ751727 JQ751728 JQ751729 JQ751730 JQ751731 JQ751732 JQ751733 JQ751734 JQ751735 JQ751736 JQ751737 JQ751738 JQ751739 JQ751740 JQ751741 JQ751742 JQ751743 JQ751744 JQ751745 JQ751746 JQ751747 JQ751748 JQ751749 JQ751750 JQ751751 JQ751752 JQ751753 JQ751754 JQ751755 JQ751756 JQ751757 JQ751758 JQ751759 JQ751760 JQ751761 JQ751762 JQ751763 JQ751764 JQ751765 JQ751766 JQ751767 JQ751768 JQ751769 JQ751770 JQ751771 JQ751772 JQ751773 JQ751774 JQ751775 JQ751776 JQ751777 JQ751778 JQ751779 JQ751780 JQ751781 JQ751782 JQ751783 JQ751784 JQ751785 JQ751786 JQ751787 JQ751788 JQ751789 JQ751790 JQ751791 JQ751792 JQ751793 JQ751794 JQ751795 JQ751796 JQ751797 JQ751798 JQ751799 JQ751800 JQ751802 JQ751803 JQ751805 JQ751806 JQ751808 JQ751810 JQ751813 JQ751814 JQ751815 JQ751816 JQ751818 JQ751819 JQ751820 JQ751822 JQ751824 JQ751825 JQ751826 JQ751827 JQ751828 JQ751829 JQ751831 JQ751833 JQ751834 JQ751835 JQ751836 JQ751839 JQ751840 JQ751841 JQ751842 JQ751843 JQ751844 JQ751845 JQ751847 JQ751848 JQ751849 JQ751850 JQ751851 JQ751852 JQ751853 JQ751854 JQ751855 JQ751856 JQ751857 JQ751858 JQ751859 JQ751860 JQ751861 JQ751862 JQ751863 JQ751864 JQ751865 JQ751866 JQ751867 JQ751868 JQ751869 JQ751870 JQ751871 JQ751872 JQ751873 JQ751874 JQ751875 JQ751876 JQ751877 JQ751878 JQ751879 JQ751880 JQ751881 JQ751882 JQ751883 JQ751884 JQ751885 JQ751886 JQ751887 JQ751888 JQ751889 JQ751890 JQ751891 JQ751892 JQ751893 JQ751894 JQ751895 JQ751896 JQ751897 JQ751898 JQ751899 JQ751900 JQ751901 JQ751902 JQ751903 JQ751904 JQ751905 JQ751906 JQ751907 JQ751908 JQ751909 JQ751910 JQ751911 JQ751912 JQ751913 JQ751914 JQ751915 JQ751916 JQ751917 JQ751918 JQ751919 JQ751920 JQ751921 JQ751922 JQ751923 JQ751928 JQ751931 JQ751933 JQ751934 JQ751936 JQ751938 JQ751939 JQ751941 JQ751947 JQ751948 JQ751952 JQ751957 JQ751958 JQ751959 JQ751961 JQ751965 JQ751966 JQ751971 JQ751972 JQ751975 JQ751979 JQ751988 JQ751993 JQ751994 JQ752001 JQ752012 JQ752017 JQ752018 JQ752019 JQ752021 JQ752023 JQ752026 JQ752027 JQ752030 JQ752033 JQ752034 JQ752035 JQ752046 JQ752047 JQ752063 JQ752064 JQ752072 JQ752073 JQ752086 JQ752087 JQ752088 JQ752089 JQ752094 JQ752096 JQ752097 JQ752098 JQ752103 JQ752104 JQ752105 JQ752106 JQ752117 JQ752118 JQ752119 JQ752120 JQ752123 JQ752124 JQ752125 JQ752126 JQ752131 JQ752137 JQ752138 JQ752139 JQ752142 JQ752144 JQ752147 JQ752154 JQ752156 JQ752162 JQ752164 JQ752171 JQ752174 JQ752179 JQ752184 JQ752186 JQ752191 JQ752194 JQ752200 JQ752202 JQ752204 JQ752205 JQ752208 JQ752209 JQ752210 JQ752211 JQ752212 JQ752216 JQ752219 JQ752220 JQ752224 JQ752226 JQ752227 JQ752231 JQ752232

GenPept

AAT40418 ABF51618 ABG67755 ABM69023 ABM69024 ABM69025 ABO28412 ABO28413 ABO28414 ABO28415 ABO28416 ABO28417 ABO28418 ABO28419 ABO28420 ABO28421 ABO28422 ABO28423 ABO28424 ABO28425 ABO28426 ABO28427 ABO28428 ABO28429 ABO28430 ABO28431 ABO28432 ABO28433 ABO28434 ABO28435 ABO28436 ABO28437 ABO28438 ABO28439 ABV21351 ACA63978 ACF95000 AEQ16481 AEQ16483 AEQ16484 AEQ16485 AGA62828 AGA62829 AGA62830 AGA62831 AGA62833 AGA62834 AGA62835 AGA62836 AGA62837 AGA62838 AGA62839 AGA62840 AGA62841 AGA62842 AGA62843 AGA62844 AGA62845 AGA62846 AGA62847 AGA62848 AGA62849 AGA62850 AGA62851 AGA62852 AGA62853 AGA62854 AGA62855 AGA62857 AGA62858 AGA62859 AGA62861 AGA62862 AGA62863 AGA62864 AGA62865 AGA62866 AGA62867 AGA62868 AGA62869 AGA62870 AGA62871 AGA62872 AGA62873 AGA62874 AGA62875 AGA62876 AGA62877 AGA62878 AGA62879 AGA62880 AGA62881 AGA62882 AGA62883 AGA62884 AGA62885 AGA62886 AGA62887 AGA62888 AGA62889 AGA62890 AGA62891 AGA62892 AGA62893 AGA62894 AGA62895 AGA62896 AGA62897 AGA62898 AGA62899 AGA62900 AGA62901 AGA62902 AGA62903 AGA62904 AGA62905 AGA62906 AGA62907 AGA62908 AGA62909 AGA62910 AGA62911 AGA62912 AGA62913 AGA62914 AGA62915 AGA62916 AGA62917 AGA62918 AGA62919 AGA62920 AGA62921 AGA62922 AGA62923 AGA62924 AGA62925 AGA62926 AGA62927 AGA62928 AGA62929 AGA62930 AGA62931 AGA62932 AGA62933 AGA62934 AGA62935 AGA62936 AGA62937 AGA62938 AGA62939 AGA62940 AGA62941 AGA62942 AGA62943 AGA62944 AGA62945 AGA62946 AGA62947 AGA62948 AGA62949 AGA62950 AGA62951 AGA62952 AGA62953 AGA62954 AGA62955 AGA62956 AGA62957 AGA62958 AGA62959 AGA62960 AGA62961 AGA62962 AGA62963 AGA62964 AGA62965 AGA62966 AGA62967 AGA62968 AGA62969 AGA62970 AGA62971 AGA62972 AGA62973 AGA62974 AGA62975 AGA62976 AGA62977 AGA62978 AGA62979 AGA62980 AGA62981 AGA62982 AGA62983 AGA62984 AGA62985 AGA62986 AGA62987 AGA62988 AGA62989 AGA62990 AGA62991 AGA62992 AGA62993 AGA62994 AGA62995 AGA62996 AGA62997 AGA62998 AGA62999 AGA63000 AGA63001 AGA63002 AGA63003 AGA63004 AGA63005 AGA63006 AGA63007 AGA63008 AGA63009 AGA63011 AGA63012 AGA63014 AGA63016 AGA63019 AGA63020 AGA63021 AGA63022 AGA63024 AGA63025 AGA63026 AGA63028 AGA63030 AGA63031 AGA63032 AGA63033 AGA63034 AGA63035 AGA63037 AGA63039 AGA63040 AGA63041 AGA63042 AGA63045 AGA63046 AGA63047 AGA63048 AGA63049 AGA63050 AGA63051 AGA63053 AGA63054 AGA63055 AGA63056 AGA63057 AGA63058 AGA63059 AGA63060 AGA63061 AGA63062 AGA63063 AGA63064 AGA63065 AGA63066 AGA63067 AGA63068 AGA63069 AGA63070 AGA63071 AGA63072 AGA63073 AGA63074 AGA63075 AGA63076 AGA63077 AGA63078 AGA63079 AGA63080 AGA63081 AGA63082 AGA63083 AGA63084 AGA63085 AGA63086 AGA63087 AGA63088 AGA63089 AGA63090 AGA63091 AGA63092 AGA63093 AGA63094 AGA63095 AGA63096 AGA63097 AGA63098 AGA63099 AGA63100 AGA63101 AGA63102 AGA63103 AGA63104 AGA63105 AGA63106 AGA63107 AGA63108 AGA63109 AGA63110 AGA63111 AGA63112 AGA63113 AGA63114 AGA63115 AGA63116 AGA63117 AGA63118 AGA63119 AGA63120 AGA63121 AGA63122 AGA63123 AGA63124 AGA63125 AGA63126 AGA63127 AGA63128 AGA63129 AGA63134 AGA63137 AGA63139 AGA63140 AGA63142 AGA63144 AGA63145 AGA63147 AGA63153 AGA63154 AGA63158 AGA63163 AGA63164 AGA63165 AGA63167 AGA63171 AGA63172 AGA63176 AGA63177 AGA63180 AGA63184 AGA63193 AGA63198 AGA63199 AGA63206 AGA63217 AGA63222 AGA63223 AGA63224 AGA63226 AGA63228 AGA63231 AGA63232 AGA63235 AGA63238 AGA63239 AGA63240 AGA63251 AGA63252 AGA63268 AGA63269 AGA63277 AGA63278 AGA63291 AGA63292 AGA63293 AGA63294 AGA63299 AGA63301 AGA63302 AGA63303 AGA63308 AGA63309 AGA63310 AGA63311 AGA63322 AGA63323 AGA63324 AGA63325 AGA63328 AGA63329 AGA63330 AGA63331 AGA63336 AGA63342 AGA63343 AGA63344 AGA63347 AGA63349 AGA63352 AGA63359 AGA63361 AGA63367 AGA63369 AGA63376 AGA63379 AGA63384 AGA63389 AGA63391 AGA63396 AGA63399 AGA63405 AGA63407 AGA63409 AGA63410 AGA63413 AGA63414 AGA63415 AGA63416 AGA63417 AGA63421 AGA63424 AGA63425 AGA63429 AGA63431 AGA63432 AGA63436 AGA63437 BAD11806

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca