InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAIP1

Summary

InnateDB Protein

IDBP-366500.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAIP1

Protein Name

poly(A) binding protein interacting protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000387729

InnateDB Gene

IDBG-19493 (PAIP1)

Protein Structure

UniProt Annotation

Function

Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. {ECO:0000269PubMed:11051545, ECO:0000269PubMed:9548260}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0008494	translation activator activity

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006413	translational initiation
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0045727	positive regulation of translation
GO:0048255	mRNA stabilization