InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LGR4

Summary

InnateDB Protein

IDBP-36651.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGR4

Protein Name

leucine-rich repeat containing G protein-coupled receptor 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000374508

InnateDB Gene

IDBG-36645 (LGR4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.

Experimentally validated
Total	200 [view]
Protein-Protein	199 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0030282	bone mineralization
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0045087	innate immune response
GO:0046849	bone remodeling
GO:0050710	negative regulation of cytokine secretion
GO:0090263	positive regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000372 Leucine-rich repeat-containing N-terminal
IPR001611 Leucine-rich repeat
IPR002131 Glycoprotein hormone receptor family
IPR003591 Leucine-rich repeat, typical subtype
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001
PF01462
PF00560
PF13504
PF13855

PRINTS

PR00237
PR00373

PIRSF

SMART

SM00013
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt