InnateDB Protein
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IDBP-367077.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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OLR1
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Protein Name
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oxidized low density lipoprotein (lectin-like) receptor 1
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Synonyms
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CLEC8A; LOX1; LOXIN; SCARE1; SLOX1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000405116
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InnateDB Gene
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IDBG-18612 (OLR1)
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Protein Structure
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Function |
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria. {ECO:0000269PubMed:11821063, ECO:0000269PubMed:12354387, ECO:0000269PubMed:9052782}.
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Subcellular Localization |
Cell membrane; Lipid-anchor. Cell membrane; Single-pass type II membrane protein. Membrane raft. Secreted. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation.
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Disease Associations |
Note=Independent association genetic studies have implicated OLR1 gene variants in myocardial infarction susceptibility.Note=OLR1 may be involved in Alzheimer disease (AD). Involvement in AD is however unclear: according to some authors (PubMed:12354387, PubMed:12810610 and PubMed:15976314), variations in OLR1 modify the risk of AD, while according to other (PubMed:15000751 and PubMed:15060104) they do not. {ECO:0000269PubMed:12384789, ECO:0000269PubMed:12807963, ECO:0000269PubMed:15860461}.
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Tissue Specificity |
Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level. {ECO:0000269PubMed:12354387, ECO:0000269PubMed:9052782, ECO:0000269PubMed:9828121}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P78380
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PhosphoSite |
PhosphoSite-
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TrEMBL |
B7ZAN8
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UniProt Splice Variant |
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Entrez Gene |
4973
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UniGene |
Hs.412484
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RefSeq |
NP_001166103
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HUGO |
HGNC:8133
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OMIM |
602601
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CCDS |
CCDS53745
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HPRD |
04003
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IMGT |
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EMBL |
AB010710
AB102861
AC024224
AF035776
AF079164
AF079165
AF079166
AF079167
AJ131757
AK292124
AK295409
AK316353
BC022295
BX344276
CH471094
DQ314885
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GenPept |
AAC82329
AAC97927
AAH22295
ABC40744
BAA24580
BAC81565
BAF84813
BAG58360
BAH14724
CAB38175
EAW96157
EAW96158
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