InnateDB Protein
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IDBP-36796.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HSD11B2
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Protein Name
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hydroxysteroid (11-beta) dehydrogenase 2
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Synonyms
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AME; AME1; HSD11K; HSD2; SDR9C3;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000316786
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InnateDB Gene
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IDBG-36794 (HSD11B2)
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Protein Structure
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Function |
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
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Subcellular Localization |
Microsome {ECO:0000269PubMed:17314322}. Endoplasmic reticulum {ECO:0000269PubMed:17314322}.
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Disease Associations |
Apparent mineralocorticoid excess (AME) [MIM:218030]: An autosomal recessive form of low-renin hypertension. It is usually diagnosed within the first years of life and is characterized by polyuria and polydipsia, failure to thrive, hypernatremia, severe hypertension with low renin and aldosterone levels, profound hypokalemia with metabolic alkalosis, and most often nephrocalcinosis. {ECO:0000269PubMed:12788846, ECO:0000269PubMed:17314322, ECO:0000269PubMed:7593417, ECO:0000269PubMed:7608290, ECO:0000269PubMed:9661590}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002198
Short-chain dehydrogenase/reductase SDR
IPR002347
Glucose/ribitol dehydrogenase
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PFAM |
PF00106
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PRINTS |
PR00080
PR00081
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PIRSF |
PIRSF000126
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P80365
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PhosphoSite |
PhosphoSite-P80365
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3291
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UniGene |
Hs.1376
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RefSeq |
NP_000187
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HUGO |
HGNC:5209
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OMIM |
614232
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CCDS |
CCDS10837
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HPRD |
01958
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IMGT |
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EMBL |
AY046280
BC036780
BC064536
CH471092
EF694683
FJ515828
U14631
U26726
U27317
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GenPept |
AAA91969
AAB48544
AAC50356
AAH36780
AAH64536
AAK91586
ABS29267
ACS13714
EAW83134
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