Version 5.4
Homo sapiens Protein: TOP2B
Summary
InnateDB Protein IDBP-368148.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP2B
Protein Name topoisomerase (DNA) II beta 180kDa
Synonyms top2beta; TOPIIB;
Species Homo sapiens
Ensembl Protein ENSP00000388216
InnateDB Gene IDBG-22611 (TOP2B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 59 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005524 ATP binding
GO:0008301 DNA binding, bending
Biological Process
GO:0006200 ATP catabolic process
GO:0006265 DNA topological change
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR002205 DNA topoisomerase, type IIA, subunit A/C-terminal
IPR013760 DNA topoisomerase, type IIA-like domain
PFAM PF00521
PRINTS
PIRSF
SMART SM00434
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL H7BZ82
UniProt Splice Variant
Entrez Gene 7155
UniGene Hs.614320
RefSeq
HUGO HGNC:11990
OMIM 126431
CCDS
HPRD 00537
IMGT
EMBL AC093416
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca