InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CELF4

Summary

InnateDB Protein

IDBP-368204.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CELF4

Protein Name

CUGBP, Elav-like family member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000410584

InnateDB Gene

IDBG-2659 (CELF4)

Protein Structure

UniProt Annotation

Function

RNA-binding protein implicated in the regulation of pre- mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Promotes exclusion of both the smooth muscle (SM) and non-muscle (NM) exons in actinin pre-mRNAs. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269PubMed:11158314, ECO:0000269PubMed:12649496, ECO:0000269PubMed:14973222, ECO:0000269PubMed:15009664, ECO:0000269PubMed:15894795}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14973222}. Cytoplasm {ECO:0000269PubMed:14973222}.

Disease Associations

Tissue Specificity

Ubiquitous. Strongly expressed in the cerebellum, hippocampus, amygdala, temporal and frontal cortex and frontal lobes. {ECO:0000269PubMed:11158314, ECO:0000269PubMed:12438720, ECO:0000269PubMed:16862542}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000900	translation repressor activity, nucleic acid binding
GO:0003676	nucleic acid binding
GO:0003729	mRNA binding
GO:0042835	BRE binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006376	mRNA splice site selection
GO:0007281	germ cell development
GO:0009790	embryo development
GO:0017148	negative regulation of translation
GO:0048026	positive regulation of mRNA splicing, via spliceosome
GO:0090394	negative regulation of excitatory postsynaptic membrane potential