InnateDB Protein
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IDBP-368281.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ELOVL7
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Protein Name
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ELOVL fatty acid elongase 7
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000402634
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InnateDB Gene
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IDBG-22899 (ELOVL7)
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Protein Structure
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Function |
Condensing enzyme that catalyzes the synthesis of saturated and polyunsaturated very long chain fatty acids. Highest activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. {ECO:0000269PubMed:19826053, ECO:0000269PubMed:20937905, ECO:0000269PubMed:21959040}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:20937905}; Multi-pass membrane protein {ECO:0000269PubMed:20937905}.
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Disease Associations |
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Tissue Specificity |
Expressed in most tissues except heart and skeletal muscle. {ECO:0000269PubMed:20937905}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006633
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fatty acid biosynthetic process
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GO:0019367
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fatty acid elongation, saturated fatty acid
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GO:0019432
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triglyceride biosynthetic process
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GO:0034626
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fatty acid elongation, polyunsaturated fatty acid
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GO:0035338
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long-chain fatty-acyl-CoA biosynthetic process
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GO:0042761
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very long-chain fatty acid biosynthetic process
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GO:0044255
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cellular lipid metabolic process
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GO:0044281
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small molecule metabolic process
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Cellular Component |
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PDB ID |
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InterPro |
IPR002076
GNS1/SUR4 membrane protein
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PFAM |
PF01151
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
A1L3X0
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PhosphoSite |
PhosphoSite-A1L3X0
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TrEMBL |
D6RBM2
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UniProt Splice Variant |
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Entrez Gene |
79993
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UniGene |
Hs.606676
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RefSeq |
NP_001284547
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HUGO |
HGNC:26292
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OMIM |
614451
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CCDS |
CCDS34164
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HPRD |
18700
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IMGT |
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EMBL |
AB181393
AC104113
AC109133
AC109579
AK027216
AL137506
BC130310
BC130312
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GenPept |
AAI30311
AAI30313
BAB15697
BAD93238
CAB70777
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