InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPRO

Summary

InnateDB Protein

IDBP-368338.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPRO

Protein Name

protein tyrosine phosphatase, receptor type, O

Synonyms

GLEPP1; NPHS6; PTP-OC; PTP-U2; PTPROT; PTPU2; R-PTP-O;

Species

Homo sapiens

Ensembl Protein

ENSP00000393449

InnateDB Gene

IDBG-21457 (PTPRO)

Protein Structure

UniProt Annotation

Function

Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Nephrotic syndrome 6 (NPHS6) [MIM:614196]: A form of nephrotic syndrome, a renal disease clinically characterized by severe proteinuria, resulting in complications such as hypoalbuminemia, hyperlipidemia and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. Some affected individuals have an inherited steroid-resistant form and progress to end-stage renal failure. {ECO:0000269PubMed:21722858}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Glomerulus of kidney. Also detected in brain, lung and placenta. {ECO:0000269PubMed:10498613}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005001	transmembrane receptor protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0016791	phosphatase activity
GO:0017147	Wnt-protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0002548	monocyte chemotaxis
GO:0003093	regulation of glomerular filtration
GO:0003105	negative regulation of glomerular filtration
GO:0006470	protein dephosphorylation
GO:0007411	axon guidance
GO:0010812	negative regulation of cell-substrate adhesion
GO:0010977	negative regulation of neuron projection development
GO:0016311	dephosphorylation
GO:0030032	lamellipodium assembly
GO:0032835	glomerulus development
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0036060	slit diaphragm assembly
GO:0072112	glomerular visceral epithelial cell differentiation
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090260	negative regulation of retinal ganglion cell axon guidance

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016328	lateral plasma membrane
GO:0030027	lamellipodium
GO:0030424	axon
GO:0030426	growth cone
GO:0043005	neuron projection
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00404

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt