InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM13

Summary

InnateDB Protein

IDBP-368552.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM13

Protein Name

tripartite motif containing 13

Synonyms

CAR; DLEU5; LEU5; RFP2; RNF77;

Species

Homo sapiens

Ensembl Protein

ENSP00000412943

InnateDB Gene

IDBG-34165 (TRIM13)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor. {ECO:0000269PubMed:17314412, ECO:0000269PubMed:21333377, ECO:0000269PubMed:22178386}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:17314412, ECO:0000269PubMed:21333377, ECO:0000269PubMed:22178386}; Single-pass membrane protein {ECO:0000269PubMed:17314412, ECO:0000269PubMed:21333377, ECO:0000269PubMed:22178386}. Note=Concentrates and colocalizes with p62/SQSTM1 and ZFYVE1 at the perinuclear endoplasmic reticulum.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0009653	anatomical structure morphogenesis
GO:0010332	response to gamma radiation
GO:0010942	positive regulation of cell death
GO:0016239	positive regulation of macroautophagy
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0032897	negative regulation of viral transcription
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051865	protein autoubiquitination
GO:1902187	negative regulation of viral release from host cell

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane
GO:0097038	perinuclear endoplasmic reticulum