Homo sapiens Protein: PRAM1
Summary
InnateDB Protein IDBP-369465.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRAM1
Protein Name PML-RARA regulated adaptor molecule 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000408342
InnateDB Gene IDBG-24943 (PRAM1)
Protein Structure
UniProt Annotation
Function May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung. {ECO:0000269PubMed:11301322}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008289 lipid binding
Biological Process
GO:0007229 integrin-mediated signaling pathway
GO:0043313 regulation of neutrophil degranulation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR001452 SH3 domain
PFAM PF00018
PF14604
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96QH2
PhosphoSite PhosphoSite-Q96QH2
TrEMBL K4DI84
UniProt Splice Variant
Entrez Gene 84106
UniGene Hs.465812
RefSeq NP_115528
HUGO HGNC:30091
OMIM 606466
CCDS CCDS45954
HPRD 05926
IMGT
EMBL AC092298 AC136469 AJ272324 BC028012 CH471139
GenPept AAH28012 CAC17767 EAW68918