InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHEK2

Summary

InnateDB Protein

IDBP-369665.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHEK2

Protein Name

CHK2 checkpoint homolog (S. pombe)

Synonyms

CDS1; CHK2; hCds1; HuCds1; LFS2; PP1425; RAD53;

Species

Homo sapiens

Ensembl Protein

ENSP00000416721

InnateDB Gene

IDBG-3314 (CHEK2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 109 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	109 [view]
Protein-Protein	103 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468

protein phosphorylation

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt