InnateDB Protein
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IDBP-36979.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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IL21
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Protein Name
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interleukin 21
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000264497
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InnateDB Gene
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IDBG-36977 (IL21)
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Protein Structure
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Function |
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. {ECO:0000250, ECO:0000269PubMed:11081504, ECO:0000269PubMed:15178704}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:11081504}.
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Disease Associations |
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Tissue Specificity |
Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. {ECO:0000269PubMed:11081504}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
5
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
GO:0002729
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positive regulation of natural killer cell cytokine production
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GO:0006955
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immune response
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GO:0007165
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signal transduction
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GO:0008284
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positive regulation of cell proliferation
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GO:0030890
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positive regulation of B cell proliferation
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GO:0032733
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positive regulation of interleukin-10 production
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GO:0032740
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positive regulation of interleukin-17 production
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GO:0032825
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positive regulation of natural killer cell differentiation
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GO:0034105
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positive regulation of tissue remodeling
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GO:0042102
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positive regulation of T cell proliferation
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GO:0042511
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positive regulation of tyrosine phosphorylation of Stat1 protein
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GO:0042517
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positive regulation of tyrosine phosphorylation of Stat3 protein
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GO:0045078
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positive regulation of interferon-gamma biosynthetic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0045954
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positive regulation of natural killer cell mediated cytotoxicity
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GO:0048469
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cell maturation
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GO:0050729
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positive regulation of inflammatory response
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Cellular Component |
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PDB ID |
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InterPro |
IPR003443
Interleukin-15/Interleukin-21 family
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PFAM |
PF02372
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9HBE4
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PhosphoSite |
PhosphoSite-Q9HBE4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
59067
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UniGene |
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RefSeq |
NP_068575
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HUGO |
HGNC:6005
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OMIM |
605384
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CCDS |
CCDS3727
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HPRD |
05650
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IMGT |
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EMBL |
AC053545
AF254069
AY763518
BC066258
BC066259
BC066260
BC066261
BC066262
BC069124
DQ645417
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GenPept |
AAG29348
AAH66258
AAH66259
AAH66260
AAH66261
AAH66262
AAH69124
AAU88182
ABG36529
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