InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CHN2

Summary

InnateDB Protein

IDBP-370037.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CHN2

Protein Name

chimerin (chimaerin) 2

Synonyms

ARHGAP3; BCH; CHN2-3; RHOGAP3;

Species

Homo sapiens

Ensembl Protein

ENSP00000406337

InnateDB Gene

IDBG-10872 (CHN2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0009967	positive regulation of signal transduction
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
IPR008936 Rho GTPase activation protein

PFAM

PF00620
PF00130

PRINTS

PIRSF

SMART

SM00324
SM00109

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P52757