InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBP1

Summary

InnateDB Protein

IDBP-370172.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBP1

Protein Name

upstream binding protein 1 (LBP-1a)

Synonyms

LBP-1a; LBP-1B; LBP1A; LBP1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000395558

InnateDB Gene

IDBG-24132 (UBP1)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269PubMed:10644752, ECO:0000269PubMed:2006421, ECO:0000269PubMed:8114710}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:8114710}.

Disease Associations

Tissue Specificity

Expressed in adrenal tissue, JEG-3, NCI-H295A, Hep-G2 and HeLa cell lines. {ECO:0000269PubMed:10644752}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0019079	viral genome replication
GO:0045892	negative regulation of transcription, DNA-templated