Version 5.4
| Homo sapiens Protein: S1PR5 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-371014.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | S1PR5 | ||||||||||||||||||
| Protein Name | sphingosine-1-phosphate receptor 5 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000416915 | ||||||||||||||||||
| InnateDB Gene | IDBG-27610 (S1PR5) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. {ECO:0000250}. | ||||||||||||||||||
| Subcellular Localization | Cell membrane; Multi-pass membrane protein. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. {ECO:0000269PubMed:11705398, ECO:0000269PubMed:12234605, ECO:0000269PubMed:12427546}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR000276
G protein-coupled receptor, rhodopsin-like IPR004061 Sphingosine 1-phosphate receptor IPR005386 EDG-8 sphingosine 1-phosphate receptor IPR017452 GPCR, rhodopsin-like, 7TM |
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| PFAM |
PF00001
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| PRINTS |
PR00237
PR01523 PR01561 |
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| PIRSF | |||||||||||||||||||
| SMART | |||||||||||||||||||
| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q9H228 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q9H228 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 53637 | ||||||||||||||||||
| UniGene | Hs.501561 | ||||||||||||||||||
| RefSeq | NP_001159687 | ||||||||||||||||||
| HUGO | HGNC:14299 | ||||||||||||||||||
| OMIM | 605146 | ||||||||||||||||||
| CCDS | CCDS12240 | ||||||||||||||||||
| HPRD | 05510 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB083602 AC011461 AF317676 AF331840 AK074661 AY262689 BC034703 BC067781 | ||||||||||||||||||
| GenPept | AAG38113 AAH34703 AAH67781 AAL57041 AAP20653 BAB89315 BAC11119 | ||||||||||||||||||