InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MLH1

Summary

InnateDB Protein

IDBP-371052.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MLH1

Protein Name

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

Synonyms

COCA2; FCC2; hMLH1; HNPCC; HNPCC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000402667

InnateDB Gene

IDBG-24600 (MLH1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.

Experimentally validated
Total	151 [view]
Protein-Protein	144 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030983	mismatched DNA binding
GO:0032407	MutSalpha complex binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006298	mismatch repair
GO:0016446	somatic hypermutation of immunoglobulin genes

Cellular Component

GO:0000795	synaptonemal complex
GO:0005634	nucleus
GO:0005712	chiasma
GO:0016020	membrane
GO:0032389	MutLalpha complex

Protein Structure and Domains

PDB ID

InterPro

IPR013507 DNA mismatch repair protein, C-terminal
IPR020568 Ribosomal protein S5 domain 2-type fold

PFAM

PF01119

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P40692

PhosphoSite

PhosphoSite-P40692

TrEMBL

E7EUC9

UniProt Splice Variant

Entrez Gene

4292

UniGene

Hs.195364

RefSeq

NP_001245203

HUGO

HGNC:7127

OMIM

120436

CCDS

CCDS54563

HPRD

00390

IMGT

EMBL

AC006583 AC011816 AK295359 AK298324 AK298583 AK302807 AK316074 AK316264 AY217549 BC006850 CH471055 EU188665 FJ940753 U07343 U07418 U17839 U17840 U17841 U17842 U17843 U17844 U17845 U17846 U17847 U17848 U17849 U17851 U17852 U17853 U17854 U17855 U17856 U17857 U40960 U40961 U40962 U40963 U40964 U40965 U40966 U40967 U40968 U40969 U40970 U40971 U40972 U40973 U40974 U40975 U40976 U40977 U40978

GenPept

AAA17374 AAA82079 AAA85687 AAC50285 AAH06850 AAO22994 ABW69161 ACR33810 BAG58325 BAG60576 BAG60773 BAH13807 BAH14445 BAH14635 EAW64483 EAW64484