InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NSMAF

Summary

InnateDB Protein

IDBP-371166.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NSMAF

Protein Name

neutral sphingomyelinase (N-SMase) activation associated factor

Synonyms

FAN;

Species

Homo sapiens

Ensembl Protein

ENSP00000411012

InnateDB Gene

IDBG-22729 (NSMAF)

Protein Structure

UniProt Annotation

Function

Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0016230	sphingomyelin phosphodiesterase activator activity

Biological Process

GO:0006672	ceramide metabolic process
GO:0007165	signal transduction
GO:0035556	intracellular signal transduction
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity